UNC2399

UNC2399, a biotinylated UNC1999, is a selective EZH2 inhibitor, maintaining high in vitro potency for EZH2, with an IC50 of 17 nM[1][2].

Product Specifications

CAS Number

[2412791-72-9]

UNSPSC

12352005

Target

Histone Methyltransferase

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/unc-2399.html

Concentration

10mM

Purity

99.16

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CCCC(C=C(NC1=O)C)=C1CNC(C2=C3C(N(N=C3)C(C)C)=CC(C4=CN=C(N5CCN(CC5)C(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCCC[C@H]6[C@]7([H])[C@](NC(N7)=O)([H])CS6)=O)=O)C=C4)=C2)=O

Molecular Formula

C67H104N10O17S

Molecular Weight

1353.66

References & Citations

[1]Konze KD, et, al. An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1. ACS Chem Biol. 2013; 8 (6) : 1324-34.|[2]Ma A, et, al. Discovery of a first-in-class EZH2 selective degrader. Nat Chem Biol. 2020 Feb;16 (2) :214-222.