What is the catalog number for CBL Antibody - C-terminal region (ARP35761_P050)?

The catalog number for CBL Antibody - C-terminal region (ARP35761_P050) is ARP35761_P050.

What sizes are available for CBL Antibody - C-terminal region (ARP35761_P050)?

CBL Antibody - C-terminal region (ARP35761_P050) is available in the following size(s): 100 µL.

Is CBL Antibody - C-terminal region (ARP35761_P050) in stock?

CBL Antibody - C-terminal region (ARP35761_P050) is currently made to order / not held in immediate stock. Contact us for lead time.

What is the purity of this recombinant protein?

Purity, typically assessed by SDS-PAGE, is listed on the datasheet under quality control data.

What do I do if this product arrives with reduced ice or a damaged cold-chain package?

Report this to us immediately with photos and your order reference. Our specialists will assess whether the product is still usable given the cold-chain interruption, and will arrange a replacement or credit if it isn’t.

What host species was used to raise this antibody?

The host species used in production is listed under product specifications on the datasheet, and is relevant when selecting a compatible secondary antibody for your assay.

CBL Antibody - C-terminal region (ARP35761_P050)

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Product Specifications

CAS Number

9007-83-4

Gene Name

Cbl proto-oncogene, E3 ubiquitin protein ligase

Gene Aliases

CBL2, NSLL, C-CBL, RNF55, FRA11B

Gene ID

867

Swiss Prot

P22681

Accession Number

NP_005179

Reactivity

Human

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human CBL

Target

This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder.

Partner Proteins

ERBB4; EGFR; SIRT2; FRS3; PRPSAP2; YWHAH; YWHAE; GRB2; CAPZA1; SH3KBP1; CD2AP; UBC; NEDD8; SUMO1; EPHA2; CRK; ERBB2; NCK2; NCK1; UBE2D2; PIK3R1; LOX; YWHAB; FLT3; IRF1; MYO1C; TNS4; WAS; UBE2D3; PTEN; EPHB1; CTNNB1; CRKL; CBL; STAT5A; SRC; SHC1; RET; ITGA

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

GEGNLAAAHANTGPEESENEDDGYDVPKPPVPAVLARRTLSDISNASSSF

Applications

Purification

Affinity purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Cow: 93%; Dog: 93%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 75%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

99 kDa

Protein Length

906

NCBI Gene Symbol

CBL

Host or Source

Rabbit

Protein Name

E3 ubiquitin-protein ligase CBL

Gene Name URL

CBL

Nucleotide Accession Number

NM_005188.3

Frequently Asked Questions

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