LIN28 Antibody - N-terminal region

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Product Specifications

CAS Number

9007-83-4

Gene Name

Lin-28 homolog A (C. elegans)

Gene Aliases

CSDD1, LIN28, LIN-28, ZCCHC1, lin-28A

Gene ID

79727

Swiss Prot

Q9H9Z2

Accession Number

NP_078950

Reactivity

Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Pig, Rabbit, Sheep, Yeast

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human LIN28

Target

LIN28 acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. The association of LIN28 with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. IT binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. LIN28 is Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression.

Partner Proteins

HNRNPUL2; HNRNPA3; DHX36; SREK1; TRIM71; LARP4; TGS1; DHX57; GADD45GIP1; LTV1; NOA1; DDX50; KRI1; NOL6; METTL17; NOC3L; ZC3HAV1; PPAN; CCBL2; MEPCE; TSR1; NHP2; NOP10; STRBP; BRIX1; RBM28; PHAX; SRRT; LARP7; DDX41; HP1BP3; NOB1; PRPF19; ZBTB11; SND1; AATF

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

GSVSNQQFAGGCAKAAEEAPEEAPEDAARAADEPQLLHGAGICKWFNVRM

Applications

IHC, WB

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Goat: 91%; Guinea Pig: 86%; Human: 100%; Mouse: 90%; Pig: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%; Yeast: 77%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

23kDa

Protein Length

209

NCBI Gene Symbol

LIN28A

Host or Source

Rabbit

Protein Name

Protein lin-28 homolog A

Gene Name URL

LIN28A

Nucleotide Accession Number

NM_024674

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