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TFB2M Antibody - N-terminal region

Product Specifications

CAS Number

9007-83-4

Gene Name

Transcription factor B2, mitochondrial

Gene Aliases

Hkp1, mtTFB2

Gene ID

64216

Swiss Prot

Q9H5Q4

Accession Number

NP_071761

Reactivity

Human, Rat, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human TFB2M

Target

TFB2M is a S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. It is also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. It stimulates transcription independently of the methyltransferase activity. Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity.

Partner Proteins

UBC; FBXO6; C1QBP; CUL3; TFB2M; POLRMT; TFAM; PNP

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

ECNPGPGILTQALLEAGAKVVALESDKTFIPHLESLGKNLDGKLRVIHCD

Applications

IHC, WB

Purification

Protein A purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

1.0 mg/ml

Homology

Horse: 100%; Human: 100%; Rabbit: 83%; Rat: 85%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

45kDa

Protein Length

396

NCBI Gene Symbol

TFB2M

Host or Source

Rabbit

Protein Name

Dimethyladenosine transferase 2, mitochondrial

Gene Name URL

TFB2M

Nucleotide Accession Number

NM_022366

Frequently Asked Questions

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