CBX1 antibody - middle region (ARP34427_T100)

Product Specifications

CAS Number

9007-83-4

Gene Name

Chromobox homolog 1

Gene Aliases

CBX, M31, MOD1, p25beta, HP1-BETA, HP1Hsbeta, HP1Hs-beta

Gene ID

10951

Swiss Prot

P83916

Accession Number

NP_006798

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human CBX1

Target

CBX1 is the component of heterochromatin. CBX1 recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. CBX1 interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane.Heterochromatin protein-1 (HP1) is localized at heterochromatin sites, where it mediates gene silencing.[supplied by OMIM].

Partner Proteins

PRDM6; SUMO1; UBC; RNF2; PARK2; NR2F6; VHL; EHMT2; ABI3BP; VTN; TRIM39; CBX5; HIST1H3B; KLF11; HIST3H3; PCNA; MECP2; ADNP; POGZ; ADNP2; CBX3; TRIM28; CHAF1A; HIST1H4F; XRCC6; CHD4; H2AFB1; NSL1; SUMO2; HIST1H3A; Mad2l2; Cbx1; DNMT3B; ZNF382; H3F3A; SUV420

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

PDLIAEFLQSQKTAHETDKSEGGKRKADSDSEDKGEESKPKKKKEESEKP

Applications

Purification

Protein A purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

1.0 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

21kDa

Protein Length

185

NCBI Gene Symbol

CBX1

Host or Source

Rabbit

Protein Name

Chromobox protein homolog 1

Gene Name URL

CBX1

Nucleotide Accession Number

NM_006807

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