XRCC5 antibody - C-terminal region (ARP34121_T100)

Product Specifications

CAS Number

9007-83-4

Gene Name

X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)

Gene Aliases

KU80, KUB2, Ku86, NFIV, KARP1, KARP-1

Gene ID

7520

Swiss Prot

Q4VBQ5

Accession Number

NP_066964

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human XRCC5

Target

XRCC5 encodes the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V (D) J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V (D) J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.

Partner Proteins

HUWE1; UBC; EHF; ELF3; SUMO2; SUMO3; BRCA1; ATRX; Fbxl16; NEDD8; SUMO1; MDM2; RPA3; RPA2; RPA1; SUZ12; EED; RNF2; BMI1; EIF4B; C1QBP; RPL24; PLCB3; PRMT3; EIF3J; CUL2; CSDE1; SF1; TRMT1; SAMHD1; DNMBP; GANAB; HYOU1; NCL; NARS; MSH2; JUP; HSPA4; PARP1; TAR

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

GITLITKEEASGSSVTAEEAKKFLAPKDKPSGDTAAVFEEGGDVDDLLDM

Applications

Purification

Protein A purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol