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STAT1 Antibody - N-terminal region

Product Specifications

CAS Number

9007-83-4

Gene Name

Signal transducer and activator of transcription 1, 91kDa

Gene Aliases

CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91

Gene ID

6772

Swiss Prot

P42224

Accession Number

NP_009330

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Sheep

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human STAT1

Target

STAT1 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens.The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described.

Partner Proteins

HUWE1; ISG15; PIAS1; UBC; STAT1; EIF1AD; OTUD4; LMO2; GNB2; DTX3L; EGFR; NAA15; SNX6; CAND1; VPS29; GSPT2; JMJD6; RTF1; HSPA4L; ATG7; YAP1; PAWR; KARS; IDE; CTTN; VPS26A; HIRIP3; NAA10; TSNAX; TBCD; SNX2; SNX1; SHMT2; SHMT1; SARS; ATP6V1C1; APEH; USP13; E

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

LQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQVLWDRTFSL

Applications

WB

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 90%; Horse: 100%; Human: 100%; Mouse: 84%; Pig: 100%; Rabbit: 92%; Rat: 84%; Sheep: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

87kDa

Protein Length

750

NCBI Gene Symbol

STAT1

Host or Source

Rabbit

Protein Name

Signal transducer and activator of transcription 1-alpha/beta

Gene Name URL

STAT1

Nucleotide Accession Number

NM_007315

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