PRDM16 Antibody - middle region

Product Specifications

CAS Number

9007-83-4

Gene Name

PR domain containing 16

Gene Aliases

MEL1, KMT8F, LVNC8, PFM13, CMD1LL

Gene ID

63976

Swiss Prot

Q9HAZ2

Accession Number

NP_071397

Reactivity

Human, Rat, Cow, Guinea Pig, Horse, Pig

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human PRDM16

Target

The reciprocal translocation t (1;3) (p36; q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) . This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t (1:3) (p36, q21) -positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Partner Proteins

TFAP4; UBC; HDAC2; Ctbp2; SUMO1; SKI; SMAD3; SMAD2; INADL

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

LNHTQDAKLPSPLGNPALPLVSAVSNSSQGTTAAAGPEEKFESRLEDSCV

Applications

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Cow: 92%; Dog: 77%; Guinea Pig: 86%; Horse: 85%; Human: 100%; Mouse: 79%; Pig: 92%; Rat: 86%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

140kDa

Protein Length

1275

NCBI Gene Symbol

PRDM16

Host or Source

Rabbit

Protein Name

PR domain zinc finger protein 16

Gene Name URL

PRDM16

Nucleotide Accession Number

NM_022114

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