S63845

Product Specifications

CAS Number

1799633-27-4

Synonyms

A (R) -[[ (5S) -5-[3-chloro-2-methyl-4-[2- (4-methyl-1-piperazinyl) ethoxy]phenyl]-6- (5-fluoro-2-furanyl) thieno[2,3-d]pyrimidin-4-yl]oxy]-2-[[1- (2,2,2-trifluoroethyl) -1H-pyrazol-5-yl]methoxy]-benzenepropanoic acid

MDL Number

MFCD31382374

Purity

98%

Smiles

CN1CCN(CCOc2ccc(c(C)c2Cl)c3c(sc4ncnc(O[C@@H](Cc5ccccc5OCc6ccnn6CC(F)(F)F)C(=O)O)c34)c7oc(F)cc7)CC1

Additionnal Information

Keep Cold

Storage Conditions

Store at 2-8°C

Notes

S63845 specifically binds with high affinity to the BH3-binding groove of MCL1. S63845 potently kills MCL1-dependent cancer cells, including multiple myeloma, leukaemia and lymphoma cells, by activating the BAX/BAK-dependent mitochondrial apoptotic pathway.