S63845
Product Specifications
CAS Number
1799633-27-4
Synonyms
A (R) -[[ (5S) -5-[3-chloro-2-methyl-4-[2- (4-methyl-1-piperazinyl) ethoxy]phenyl]-6- (5-fluoro-2-furanyl) thieno[2,3-d]pyrimidin-4-yl]oxy]-2-[[1- (2,2,2-trifluoroethyl) -1H-pyrazol-5-yl]methoxy]-benzenepropanoic acid
MDL Number
MFCD31382374
Purity
98%
Smiles
CN1CCN(CCOc2ccc(c(C)c2Cl)c3c(sc4ncnc(O[C@@H](Cc5ccccc5OCc6ccnn6CC(F)(F)F)C(=O)O)c34)c7oc(F)cc7)CC1
Additionnal Information
Keep Cold
Storage Conditions
Store at 2-8°C
Notes
S63845 specifically binds with high affinity to the BH3-binding groove of MCL1. S63845 potently kills MCL1-dependent cancer cells, including multiple myeloma, leukaemia and lymphoma cells, by activating the BAX/BAK-dependent mitochondrial apoptotic pathway.
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