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DMAP1 antibody - N-terminal region (ARP32917_T100)

Product Specifications

CAS Number

9007-83-4

Gene Name

DNA methyltransferase 1 associated protein 1

Gene Aliases

EAF2, SWC4, MEAF2, DNMAP1, DNMTAP1

Gene ID

55929

Swiss Prot

Q9NPF5

Accession Number

NP_001029196

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human DMAP1

Target

DMAP1 is a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described.

Partner Proteins

SOX2; UBC; RNF2; HECW2; RUVBL2; SRCAP; CFDP1; RUVBL1; DENR; VPS72; TOMM34; TSG101; H2AFZ; DAXX; SMARCAD1; SUMO2; EPC1; ACTL6A; ACTA1; PPP2R2D; ING3; MORF4L1; BRD8; KAT5; TRRAP; YEATS4; EP400; EPC2; MYC; MAX; ACTG1; ACTB; MRGBP; MORF4L2; MNAT1; HDAC1; tat

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

DAWTKAETDHLFDLSRRFDLRFVVIHDRYDHQQFKKRSVEDLKERYYHIC

Applications

WB

Purification

Protein A purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

1.0 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 86%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

51kDa

Protein Length

467

NCBI Gene Symbol

DMAP1

Host or Source

Rabbit

Protein Name

DNA methyltransferase 1-associated protein 1

Gene Name URL

DMAP1

Nucleotide Accession Number

NM_001034024

Frequently Asked Questions

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