COPS5 Antibody - N-terminal region

Product Specifications

CAS Number

9007-83-4

Gene Name

COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)

Gene Aliases

CSN5, JAB1, SGN5, MOV-34

Gene ID

10987

Swiss Prot

Q92905

Accession Number

NP_006828

Reactivity

Human

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human COPS5

Target

The protein encoded by COPS5 is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors.

Partner Proteins

COPS6; UBC; CUL1; NEDD8; PTGS2; GPS1; LRP1; RANBP9; APP; SIAH1; BACE1; CTNNB1; COPS5; STAT3; CREB3; COPS4; SART3; COPS3; EPB41L1; CAST; KIF5B; PDLIM7; SMAD4; FBXO6; COPS2; TYK2; CDK2; CENPW; CENPT; FBXW4; MYEOV2; COPS8; CHUK; IKBKB; DTL; CD93; DDO; SMAD2

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

NMQEAQSIDEIYKYDKKQQQEILAAKPWTKDHHYFKYCKISALALLKMVM

Applications

IHC, WB

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol