SMAD6 Antibody - N-terminal region

Product Specifications

CAS Number

9007-83-4

Gene Name

SMAD family member 6

Gene Aliases

AOVD2, MADH6, MADH7, HsT17432

Gene ID

4091

Swiss Prot

O43541

Accession Number

NP_005576

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human SMAD6

Target

SMAD6 (mothers against decapentaplegic homolog 6) is an antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD.

Partner Proteins

ITCH; SMURF2; BPIFA1; NEDD4L; WWP2; WWP1; USP15; USP11; PIGR; NASP; LYZ; KPNA2; CTBP2; CTBP1; UBC; ACVR1; UBE2O; BAMBI; STAMBP; ACTR1B; TGFBR1; MYD88; SMAD1; BMPR2; BMPR1B; BMPR1A; ACVR2B; ACVR1B; SMURF1; PELI1; CUL2; ELAVL1; SMAD5; RPS6KA5; TSC22D1; MAPK

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

APRDASDPLAGAALEPAGGGRSREARSRLLLLEQELKTVTYSLLKR

Applications

IHC, WB

Purification

Protein A purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

1.0 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 91%; Human: 100%; Mouse: 100%; Pig: 100%; Rat: 100%; Zebrafish: 86%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

53kDa

Protein Length

496

NCBI Gene Symbol

SMAD6

Host or Source

Rabbit

Protein Name

Mothers against decapentaplegic homolog 6

Gene Name URL

SMAD6

Nucleotide Accession Number

NM_005585

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

MBS8115316-01 0.3 mg

Human GBP2 HEK293 Overexpression Lysate

Ask

View Details

MBS8115316-02 5x 0.3 mg

Human GBP2 HEK293 Overexpression Lysate

Ask

View Details

MBS9608753-01 0.1 mL

LSS Antibody

Ask

View Details

MBS9608753-02 0.2 mL

LSS Antibody

Ask

View Details

MBS9608753-03 5x 0.2 mL

LSS Antibody

Ask

View Details

H00001108-M01-100ug 100 µg

Mouse Monoclonal CHD4 Antibody (4H4)

Ask

View Details