PTK2B antibody - C-terminal region (ARP32684_T100)

Product Specifications

CAS Number

9007-83-4

Gene Name

PTK2B protein tyrosine kinase 2 beta

Gene Aliases

PKB, PTK, CAKB, FAK2, PYK2, CADTK, FADK2, RAFTK

Gene ID

2185

Swiss Prot

Q14289

Accession Number

NP_004094

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human PTK2B

Target

PTK2B encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies.

Partner Proteins

CBLB; UBC; EGFR; PXN; HSP90AA1; MAPT; GP6; TRAF4; BCAR1; SKAP2; GP1BB; UL49; SOCS3; SRC; GRB2; FYN; DNM1; ALG2; SH3KBP1; PDCD6IP; CBL; SOCS2; PTEN; MBD2; DLGAP3; STAP1; SORBS2; NEDD9; EFS; NPHP1; PITPNM2; PITPNM3; PITPNM1; ARHGAP21; RB1CC1; ASAP1; LPXN; P

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

QKQMVEDYQWLRQEEKSLDPMVYMNDKSPLTPEKEVGYLEFTGPPQKPPR

Applications

Purification

Protein A purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol