UHRF1 Antibody - C-terminal region (ARP32596_P050)
Selected Variant
ARP32596_P050
Size: 100 µL
Product Specifications
CAS Number
9007-83-4
Gene Name
Ubiquitin-like with PHD and ring finger domains 1
Gene Aliases
Np95, hNP95, ICBP90, RNF106, TDRD22, hUHRF1, huNp95
Gene ID
29128
Swiss Prot
Q96T88
Reactivity
Human
Immunogen
The immunogen is a synthetic peptide directed towards the C-terminal region of Human UHRF1
Target
This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. Multiple transcript variants encoding different isoforms have been found for this gene.
Partner Proteins
UBC; H3F3B; H3F3A; HIST2H3D; HIST2H3A; HIST2H3C; UHRF1; HIST1H3F; HIST1H3B; HIST1H3E; HIST1H3C; HIST1H3D; HIST1H3A; HIST3H3; DNMT1; PARP1; PARP2; RNF2; USP7; KAT5; MPG; BTRC; CUL1; ZPR1; RB1; PRKACA; PML; SUV39H1; EZH2; SUZ12; UHRF2; USP11; HDAC1; ELAVL1
Clonality
Polyclonal
Type
Polyclonal Antibody
Sequence
DDEPGPWTKEGKDRIKKLGLTMQYPEGYLEALANREREKENSKREEEEQQ
Applications
WB
Purification
Affinity Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Homology
Human: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Molecular Weight
90kDa
Protein Length
793
NCBI Gene Symbol
UHRF1
Host or Source
Rabbit
Protein Name
E3 ubiquitin-protein ligase UHRF1
Gene Name URL
UHRF1
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