ESR2 Antibody - N-terminal region

Product Specifications

CAS Number

9007-83-4

Gene Name

Estrogen receptor 2 (ER beta)

Gene Aliases

Erb, ESRB, ODG8, ESTRB, NR3A2, ER-BETA, ESR-BETA

Gene ID

2100

Swiss Prot

Q92731-7

Reactivity

Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Pig, Rabbit, Sheep

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human ESR2

Target

ESR2 is a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized.

Partner Proteins

PLSCR1; MEOX2; NOTCH2NL; RFX6; MMS19; BCAS2; NCOA1; RPS18; MRPS15; MRPS22; ZC3HAV1; PTCD3; EXOSC4; MRPS2; MED4; MRPS27; MRPS31; MED17; TRIM24; NRIP1; NCOA3; STAU1; SP1; PABPC5; MYLK2; RPS11; RPS4X; RPLP0; RPL36AL; PPP5C; HSPA8; ESR2; ESR1; ACTB; SRA1; ARI

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

TPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVNRETLKRKVSGN

Applications

Purification

Protein A purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

1.0 mg/ml

Homology

Cow: 100%; Dog: 93%; Goat: 93%; Guinea Pig: 93%; Horse: 79%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 85%; Rat: 100%; Sheep: 93%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

48kDa

Specificity

Directed towards isoforms 1-8.

Protein Length

439

NCBI Gene Symbol

ESR2

Host or Source

Rabbit

Protein Name

Estrogen receptor beta

Gene Name URL

ESR2

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