FAS Antibody - middle region
Product Specifications
CAS Number
9007-83-4
Gene Name
Fas (TNF receptor superfamily, member 6)
Gene Aliases
APT1, CD95, FAS1, APO-1, FASTM, ALPS1A, TNFRSF6
Gene ID
355
Swiss Prot
P25445
Accession Number
NP_000034
Reactivity
Human, Pig
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human FAS
Target
FAS is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. At least eight alternatively spliced transcript variants encoding seven distinct isoforms have been described. The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.
Partner Proteins
FADD; CAV1; FAS; APOA5; TMX1; UBQLN1; MBD4; TP63; TCAP; BAG6; UBC; HNRNPC; GADD45A; CCND3; ATP6V0B; SQSTM1; Ube2i; PRAM1; RARA; PML; DAXX; FASLG; TRADD; MAP3K5; BMX; Traf1; FAF1; FAF2; TRAF3; KRIT1; TNF; BRE; LRIF1; FEM1B; FBF1; FAIM2; CASP8AP2; C14orf1
Clonality
Polyclonal
Type
Polyclonal Antibody
Sequence
KKEAYDTLIKDLKKANLCTLAEKIQTIILKDITSDSENSNFRNEIQSLV
Applications
WB
Purification
Affinity Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Homology
Human: 100%; Pig: 80%
Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Molecular Weight
36kDa
Protein Length
335
NCBI Gene Symbol
FAS
Host or Source
Rabbit
Protein Name
Tumor necrosis factor receptor superfamily member 6
Gene Name URL
FAS
Nucleotide Accession Number
NM_000043
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