RAD17 Antibody - N-terminal region

Product Specifications

CAS Number

9007-83-4

Gene Name

RAD17 homolog (S. pombe)

Gene Aliases

CCYC, R24L, RAD24, HRAD17, RAD17SP

Gene ID

5884

Swiss Prot

O75943-2

Accession Number

NP_002864

Reactivity

Human, Rat, Cow, Dog, Horse, Pig, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human RAD17

Target

RAD17 is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by ATR after the damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation.

Partner Proteins

USP20; UBC; PRMT6; CBX7; CBX6; RAD9A; CDH1; ATR; RFC1; H2AFX; FOXO3; ATM; CLSPN; ALK; RAD9B; POLE; HUS1; RAD1; NHP2L1; MCM7; RFC4; RFC5; RFC3; RFC2; POLE4; POLE3; POLE2; PRKDC

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

MNQVTDWVDPSFDDFLECSGVSTITATSLGVNNSSHRRKNGPSTLESSRF

Applications

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Cow: 89%; Dog: 100%; Horse: 92%; Human: 100%; Pig: 100%; Rabbit: 100%; Rat: 89%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

76kDa

Protein Length

670

NCBI Gene Symbol

RAD17

Host or Source

Rabbit

Protein Name

Cell cycle checkpoint protein RAD17

Gene Name URL

RAD17

Nucleotide Accession Number

NM_002873

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