ARRB1 antibody - middle region (ARP30523_P050)
Product Specifications
CAS Number
9007-83-4
Gene Name
Arrestin, beta 1
Gene Aliases
ARB1, ARR1
Gene ID
408
Swiss Prot
P49407
Accession Number
NP_004032
Reactivity
Human, Cow, Dog, Horse
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human ARRB1
Target
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described, however, their exact functions are not known.
Partner Proteins
MAPK9; UBC; PTGER4; SRC; GNMT; NOTCH1; ARRDC1; PTAFR; MAP2K3; LIMK1; PDXP; MAPK14; CLTC; CFL1; AP2A1; MAP3K5; AKT1; AGTR1; MAP2K4; MAPK10; CSK; EDNRA; Agtr1a; NEK6; PIK3R2; NFKBIA; AXIN1; YY1; BTK; BAG1; ADRB1; ADH6; RPL15; PDE4D; Mlnr; Trhr; ARRDC4; ARRD
Clonality
Polyclonal
Type
Polyclonal Antibody
Sequence
NETPVDTNLIELDTNDDDIVFEDFARQRLKGMKDDKEEEEDGTGSPQLNN
Applications
WB
Purification
Affinity Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Homology
Cow: 90%; Dog: 100%; Horse: 100%; Human: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Molecular Weight
47kDa
Protein Length
418
NCBI Gene Symbol
ARRB1
Host or Source
Rabbit
Protein Name
Beta-arrestin-1
Gene Name URL
ARRB1
Nucleotide Accession Number
NM_004041
Curated Selection
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