CRK Antibody - C-terminal region
Product Specifications
CAS Number
9007-83-4
Gene Name
V-crk sarcoma virus CT10 oncogene homolog (avian)
Gene Aliases
P38, CRKII
Gene ID
1398
Swiss Prot
P46108
Accession Number
NP_058431
Reactivity
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse
Target
This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.
Partner Proteins
FAM154A; HUWE1; ABL2; ABL1; SPRR2A; MET; CBL; BAG3; LMNA; ERBB3; ERBB2; EGFR; PPFIBP2; ATXN1; PTPN4; MAPK4; DOK1; BCAR1; NANS; FUBP1; SPR; HSPB1; DHX9; SERPINH1; ATIC; PIK3R2; PIK3R1; PIK3CD; PIK3CB; PIK3CA; PIK3C2B; SERPINB6; LYZ; KRT19; KRT17; KRT16; KR
Clonality
Polyclonal
Type
Polyclonal Antibody
Sequence
IPVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPEPGPYAQPSVNTPLP
Applications
WB
Purification
Affinity Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rat: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Molecular Weight
34kDa
Protein Length
304
NCBI Gene Symbol
CRK
Host or Source
Rabbit
Protein Name
Adapter molecule crk
Gene Name URL
CRK
Nucleotide Accession Number
NM_016823
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