TYK2 Antibody - C-terminal region

Product Specifications

CAS Number

9007-83-4

Gene Name

Tyrosine kinase 2

Gene Aliases

JTK1, IMD35

Gene ID

7297

Swiss Prot

P29597

Accession Number

NP_003322

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human TYK2

Target

This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.

Partner Proteins

KHDRBS2; KRT40; TRAF4; HNRNPK; FHL3; COPS5; JAK3; UBC; HSP90AA1; TYK2; PTAFR; EIF2AK2; LNX1; KLF10; SOCS1; TK1; DNM2; IFNAR1; JAKMIP1; XRCC5; STAM2; PRMT5; IFNAR2; CRKL; GHR; IRS2; IL6ST; STAT2; STAT1; IL13RA1; GNB2L1; PTPN1; PTPN6; PDGFRB; PLAUR; PIK3R1

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

HRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAP

Applications

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Cow: 91%; Dog: 100%; Guinea Pig: 91%; Horse: 100%; Human: 100%; Mouse: 100%; Rat: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

134kDa

Protein Length

1187

NCBI Gene Symbol

TYK2

Host or Source

Rabbit

Protein Name

Non-receptor tyrosine-protein kinase TYK2

Gene Name URL

TYK2

Nucleotide Accession Number

NM_003331

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