TYK2 antibody - C-terminal region (ARP30319_P050)

Product Specifications

CAS Number

9007-83-4

Gene Name

Tyrosine kinase 2

Gene Aliases

JTK1, IMD35

Gene ID

7297

Swiss Prot

P29597

Accession Number

NP_003322

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human TYK2

Target

This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.

Partner Proteins

KHDRBS2; KRT40; TRAF4; HNRNPK; FHL3; COPS5; JAK3; UBC; HSP90AA1; TYK2; PTAFR; EIF2AK2; LNX1; KLF10; SOCS1; TK1; DNM2; IFNAR1; JAKMIP1; XRCC5; STAM2; PRMT5; IFNAR2; CRKL; GHR; IRS2; IL6ST; STAT2; STAT1; IL13RA1; GNB2L1; PTPN1; PTPN6; PDGFRB; PLAUR; PIK3R1

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

HRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAP

Applications

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol