TERT Antibody - C-terminal region (ARP30229_P050)
Product Specifications
CAS Number
9007-83-4
Gene Aliases
TP2, TRT, CMM9, EST2, TCS1, hTRT, DKCA2, DKCB4, hEST2, PFBMFT1
Gene ID
7015
Swiss Prot
O14746
Accession Number
NP_937983
Reactivity
Human
Immunogen
The immunogen is a synthetic peptide directed towards the C-terminal region of Human TERT
Target
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.
Partner Proteins
TPP1; AKT1; HSP90AA1; HSPA4; DDX51; C19orf40; STEAP4; PBK; PHF20L1; TIMM21; PABPC1; SERBP1; SLC7A11; U2SURP; CCT5; ACAA2; TUBA1B; DYNLL1; UBE2D3; TGFBR2; PPIA; PFDN1; IREB2; GLA; ENO1; EIF2S1; ATP5B; ANXA2; CIB1; UBC; vpr; VPRBP; RUVBL2; RUVBL1; TERC; DKC
Clonality
Polyclonal
Type
Polyclonal Antibody
Sequence
HQAFLLKLTRHRVTYVPLLGSLRTAQTQLSRKLPGTTLTALEAAANPALP
Applications
WB
Purification
Affinity Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Homology
Human: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Molecular Weight
127kDa
Protein Length
1132
NCBI Gene Symbol
TERT
Host or Source
Rabbit
Protein Name
Telomerase reverse transcriptase
Gene Name URL
TERT
Nucleotide Accession Number
NM_198253
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