CDKN1A Antibody - N-terminal region

Product Specifications

CAS Number

9007-83-4

Gene Name

Cyclin-dependent kinase inhibitor 1A (p21, Cip1)

Gene Aliases

P21, CIP1, SDI1, WAF1, CAP20, CDKN1, MDA-6, p21CIP1

Gene ID

1026

Swiss Prot

Q6FI05

Accession Number

NP_510867

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Sheep

Immunogen

The immunogen is a synthetic peptide directed towards the N-terminal region of Human CDKN1A

Target

This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene.

Partner Proteins

CCND1; PCNA; KRT31; TRIM54; TEX11; IKZF3; UBC; TRAF1; TCF4; SKP2; CCND3; CCND2; PHKG2; PHKA1; NCL; HSPA9; HSPA8; HSPA5; HSPA2; HSPA1A; HNRNPA2B1; CDK2; CDK5; CDK4; CDK3; CDC20; CCNE1; CCNB1; CCNA2; CAMK2D; ABR; GIGYF2; ANKRD17; UBR4; SNRNP200; FBXO21; PUF

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

KACRRLFGPVDSEQLSRDCDALMAGCIQEARERWNFDFVTETPLEGDFAW

Applications

IHC

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol