Amifostine thiol (dihydrochloride)

Amifostine thiol (WR-1065) dihydrochloride can protect normal tissues from the toxic effects of certain cancer agents and activate p53 through a JNK-dependent signaling pathway.

Product Specifications

CAS Number

[14653-77-1]

Product Name Alternative

WR-1065 (dihydrochloride)

UNSPSC

12352211

Hazard Statement

H302, H318

Target

MDM-2/p53

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/WR-1065_dihydrochloride.html

Purity

99.27

Solubility

DMSO : 17.5 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 100 mg/mL

Smiles

NCCCNCCS.Cl.Cl

Molecular Formula

C5H16Cl2N2S

Molecular Weight

207.16

Precautions

H302, H318

References & Citations

[1]Pluquet O, et al. The cytoprotective aminothiol WR1065 activates p53 through a non-genotoxic signaling pathway involving c-Jun N-terminal kinase. J Biol Chem. 2003 Apr 4;278 (14) :11879-87.|[2]Shen H, et al. Binding of the aminothiol WR-1065 to transcription factors influences cellular response to anticancer drugs. J Pharmacol Exp Ther. 2001 Jun;297 (3) :1067-73.|[3]Afshin Kheradmand, et al. Effect of WR-1065 on 6-hydroxydopamine-induced catalepsy and IL-6 level in rats. Iran J Basic Med Sci. 2016 May; 19 (5) : 490-496.