TWEAK/TNFSF12, Rat (HEK293, Fc)

TWEAK Protein refers to the cytokine tumor necrosis factor-like weak inducer of apoptosis, belongs to tumor necrosis factor (TNF) superfamily. TWEAK protein binds to FN14 and TNRFSF12/APO3, is a weak inducer of apoptosis[1]. TWEAK does have pro-apoptotic activity for tumor cell, mediates NF-kappa-B activation, promotes angiogenesis and the proliferation of endothelial cells (ECs)[2]. TWEAK also increases IL-6 and IL-8 secretion, and could potentiate the pro-inflammatory activities of TNF and IL-1[3]. TWEAK protein is a type II transmembrane protein (M1-H249) with a transmembrane domain. TWEAK/TNFSF12 Protein, Rat (HEK293, Fc) is produced by HEK293 cells (R105-H249) with N-terminal rFc-tag.

RAIAAHYEVH PQPGQDGAQA GVDGTVSGWE ETKINSSSPL RYDRQIGEFT VIRAGLYYLY CQVHFDEGKA VYLKLDLLVN GVLALRCLEE FSATAASSPG PQLRLCQVSG LLPLRPGSSL RIRTLPWAHL KAAPFLTYFG LFQVH

[1]Wiley SR, et al. TWEAK, a member of the TNF superfamily, is a multifunctional cytokine that binds the TweakR/Fn14 receptor. Cytokine Growth Factor Rev. 2003 Jun-Aug;14(3-4):241-9.|[2]Lammens A, et al. Crystal structure of human TWEAK in complex with the Fab fragment of a neutralizing antibody reveals insights into receptor binding. PLoS One. 2013 May 8;8(5):e62697.|[3]Lynch CN, et al. TWEAK induces angiogenesis and proliferation of endothelial cells. J Biol Chem. 1999 Mar 26;274(13):8455-9.|[4]Yang B, et al. TWEAK protects cardiomyocyte against apoptosis in a PI3K/AKT pathway dependent manner. Am J Transl Res. 2016 Sep 15;8(9):3848-3860.