CID755673
CID755673 is a potent PKD inhibitor with IC50s of 182 nM, 280 nM and 227 nM for PKD1, PKD2 and PKD3, respectively.
Product Specifications
CAS Number
[521937-07-5]
UNSPSC
12352005
Hazard Statement
H302, H319
Target
PKD
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/CID755673.html
Purity
99.13
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1NCCCC2=C1OC3=CC=C(O)C=C32
Molecular Formula
C12H11NO3
Molecular Weight
217.22
Precautions
H302, H319
References & Citations
[1]Sharlow ER, et al. Potent and selective disruption of protein kinase D functionality by a benzoxoloazepinolone. J Biol Chem. 2008 Nov 28;283 (48) :33516-26.|[2]Venardos K, et al. The PKD inhibitor CID755673 enhances cardiac function in diabetic db/db mice. PLoS One. 2015 Mar 23;10 (3) :e0120934.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PKD1; PKD2; PKD3
Available Sizes
Curated Selection
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