DS69910557

DS69910557 is a potent, selective and orally activehuman parathyroid hormone receptor 1 (hPTHR1) antagonist. DS69910557 has antagonistic activity for PTHR1 with an IC50 value of 0.08 μM. DS69910557 can be used for the research of hyperparathyroidism, hypercalcemia of malignancy and osteoporosis[1].

Product Specifications

CAS Number

[3032750-17-4]

UNSPSC

12352005

Target

PTHR

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ds69910557.html

Purity

99.47

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

ClC(C=N1)=CC(C2=C(C=C(Cl)C=C2)N3C4=CC=C(N5CC(F)(CN[C@@H]6CC[C@@H](C(O)=O)CC6)C5)C=C4)=C1C(C)(C)C3=O

Molecular Formula

C32H33Cl2FN4O3

Molecular Weight

611.53

References & Citations

[1]Yoshikazu Arai, et al. Lead optimization of pyrido[2,3-d][1]benzazepin-6-one derivatives leading to the discovery of a potent, selective, and orally available human parathyroid hormone receptor 1 (hPTHR1) antagonist (DS69910557) . Bioorg Med Chem. 2022 Jun 15;64:116763.