FLT3-IN-6
Product Specifications
UNSPSC Description
FLT3-IN-6 is a potent and selective inhibitor of FLT3-ITD (FLT3 mutation) with an IC50 of 1.336 nM[1].
Target Antigen
FLT3
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/flt3-in-6.html
Purity
99.14
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C(NC2CCN(C)CC2)C=C1)NC3=NNC(C4=CC=C(OCO5)C5=C4)=C3
Molecular Weight
419.48
References & Citations
[1]Heng H, et al. Combining structure- and property-based optimization to identify selective FLT3-ITD inhibitors with good antitumor efficacy in AML cell inoculated mouse xenograft model. Eur J Med Chem. 2019 Aug 15;176:248-267.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-128572/FLT3-IN-6-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-128572/FLT3-IN-6-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2377141-31-4
Available Sizes
Curated Selection
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