Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

UCB-J

UCB-J is a ligand for the synaptic vesicle protein 2A (SV2A) with a pIC50 of 8.2. UCB-J can be used as a PET tracer for SV2A to assist in the diagnosis of epilepsy research[1][2][3][4].

Product Specifications

CAS Number

[2242957-52-2]

UNSPSC

12352005

Target

Synaptic Vesicle Proteins

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ucb-j.html

Purity

99.62

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C[C@@](C2=CC(F)=C(C(F)=C2)F)([H])CN1CC3=CC=NC=C3C

Molecular Formula

C17H15F3N2O

Molecular Weight

320.31

References & Citations

[1]Joël Mercier, et al. Discovery of heterocyclic nonacetamide synaptic vesicle protein 2A (SV2A) ligands with single-digit nanomolar potency: opening avenues towards the first SV2A positron emission tomography (PET) ligands. ChemMedChem. 2014 Apr;9 (4) :693-8.|[2]Aline Delva, et al. Loss of Presynaptic Terminal Integrity in the Substantia Nigra in Early Parkinson's Disease. Mov Disord. 2020 Aug 7.|[3]Nabeel B Nabulsi, et al. Synthesis and Preclinical Evaluation of 11C-UCB-J as a PET Tracer for Imaging the Synaptic Vesicle Glycoprotein 2A in the Brain. J Nucl Med. 2016 May;57 (5) :777-84.|[4]Zhengxin Cai, et al. Synthesis and Preclinical Evaluation of an 18 F-Labeled Synaptic Vesicle Glycoprotein 2A PET Imaging Probe: [ 18 F]SynVesT-2. ACS Chem Neurosci. 2020 Feb 19;11 (4) :592-603.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-136873/UCB-J-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-136873/UCB-J-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

Phase 2

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Padi2 Rat siRNA Oligo Duplex (Locus ID 29511)
SR511737 1 Kit

Padi2 Rat siRNA Oligo Duplex (Locus ID 29511)

Ask
View Details
FGD6 shRNA (h) Lentiviral Particles
sc-95963-V 200 µL

FGD6 shRNA (h) Lentiviral Particles

Ask
View Details
Collagen 5 alpha 2 Antibody
E51A09404 100 µL

Collagen 5 alpha 2 Antibody

Ask
View Details
PacBlue Anti-human/ non-human primates CD184 Antibody *12G5*
118401I0-AAT 100 Tests

PacBlue Anti-human/ non-human primates CD184 Antibody *12G5*

Ask
View Details
RPA2 Antibody - N-terminal region : HRP (ARP62494_P050-HRP)
ARP62494_P050-HRP 100 µL

RPA2 Antibody - N-terminal region : HRP (ARP62494_P050-HRP)

Ask
View Details
RN5S133 AAV Vector (Human) (CMV)
39689101 1 μg

RN5S133 AAV Vector (Human) (CMV)

Ask
View Details