PD-168077 maleate
PD-168077 maleate is a selective dopamine D4 receptor agonist, with a Ki of 9 nM.
Product Specifications
CAS Number
[630117-19-0]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/PD-168077_maleate.html
Purity
99.60
Solubility
DMSO : 150 mg/mL (ultrasonic) |H2O : 2 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(NCN1CCN(C2=CC=CC=C2C#N)CC1)C3=CC=CC(C)=C3.O=C(O)/C=C\C(O)=O
Molecular Formula
C24H26N4O5
Molecular Weight
450.49
Precautions
H302, H315, H319, H335
References & Citations
[1]Clifford JJ, et al. Topographically based search for an "Ethogram" among a series of novel D (4) dopamine receptor agonists and antagonists. Neuropsychopharmacology. 2000 May;22 (5) :538-44.|[2]Gu Z, et al. Activation of dopamine D4 receptors induces synaptic translocation of Ca2+/calmodulin-dependent protein kinase II in cultured prefrontal cortical neurons. Mol Pharmacol. 2006 Mar;69 (3) :813-22.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
D4 Receptor
Available Sizes
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