PD-168077 maleate

PD-168077 maleate is a selective dopamine D4 receptor agonist, with a Ki of 9 nM.

Product Specifications

CAS Number

[630117-19-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/PD-168077_maleate.html

Purity

99.60

Solubility

DMSO : 150 mg/mL (ultrasonic) |H2O : 2 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(NCN1CCN(C2=CC=CC=C2C#N)CC1)C3=CC=CC(C)=C3.O=C(O)/C=C\C(O)=O

Molecular Formula

C24H26N4O5

Molecular Weight

450.49

Precautions

H302, H315, H319, H335

References & Citations

[1]Clifford JJ, et al. Topographically based search for an "Ethogram" among a series of novel D (4) dopamine receptor agonists and antagonists. Neuropsychopharmacology. 2000 May;22 (5) :538-44.|[2]Gu Z, et al. Activation of dopamine D4 receptors induces synaptic translocation of Ca2+/calmodulin-dependent protein kinase II in cultured prefrontal cortical neurons. Mol Pharmacol. 2006 Mar;69 (3) :813-22.