Fosmanogepix
Fosmanogepix (APX001) is a broad-spectrum agent against invasive fungal infections. Fosmanogepix (APX001) targets the conserved Gwt1 enzyme required for the localization of glycosylphosphatidylinositol-anchored mannoproteins in fungi. This inhibition prevents the appropriate localization of cell wall mannoproteins, which compromises cell wall integrity, biofilm formation, germ tube formation, and fungal growth. Fosmanogepix (APX001) can be used for invasive fungal infections research[1].
Product Specifications
Product Name Alternative
APX001; E1211
UNSPSC
12352005
Target
Fungal
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/fosmanogepix.html
Purity
97.0
Solubility
1 M HCl : 50 mg/mL (ultrasonic) |DMSO : 5 mg/mL (ultrasonic; adjust pH to 3 with HCl)
Smiles
O=P(OC[N+]1=CC=CC(C2=CC(CC3=CC=C(COC4=NC=CC=C4)C=C3)=NO2)=C1N)(O)[O-]
Molecular Formula
C22H21N4O6P
Molecular Weight
468.40
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-119726/Fosmanogepix-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-119726/Fosmanogepix-SDS-MedChemExpress.pdf
Scientific Category
Reference compound1
Clinical Information
Phase 3
CAS Number
[2091769-17-2]
Available Sizes
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