Fosmanogepix

Fosmanogepix (APX001) is a broad-spectrum agent against invasive fungal infections. Fosmanogepix (APX001) targets the conserved Gwt1 enzyme required for the localization of glycosylphosphatidylinositol-anchored mannoproteins in fungi. This inhibition prevents the appropriate localization of cell wall mannoproteins, which compromises cell wall integrity, biofilm formation, germ tube formation, and fungal growth. Fosmanogepix (APX001) can be used for invasive fungal infections research[1].

Product Specifications

CAS Number

[2091769-17-2]

Product Name Alternative

APX001; E1211

UNSPSC

12352005

Target

Fungal

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/fosmanogepix.html

Purity

97.0

Solubility

1 M HCl : 50 mg/mL (ultrasonic) |DMSO : 5 mg/mL (ultrasonic; adjust pH to 3 with HCl)

Smiles

O=P(OC[N+]1=CC=CC(C2=CC(CC3=CC=C(COC4=NC=CC=C4)C=C3)=NO2)=C1N)(O)[O-]

Molecular Formula

C22H21N4O6P

Molecular Weight

468.40

References & Citations

[1]Gebremariam T, et al. APX001 Is Effective in the Treatment of Murine Invasive Pulmonary Aspergillosis. Antimicrob Agents Chemother. 2019 Jan 29;63 (2) . pii: e01713-18.|[2]Shaw KJ, et al. In Vitro and In Vivo Evaluation of APX001A/APX001 and Other Gwt1 Inhibitors against Cryptococcus. Antimicrob Agents Chemother. 2018 Jul 27;62 (8) . pii: e00523-18.|[3]Shaw KJ, et al. In Vitro and In Vivo Evaluation of APX001A/APX001 and Other Gwt1 Inhibitors against Cryptococcus. Antimicrob Agents Chemother. 2018 Jul 27;62 (8) :e00523-18.