14,15-EET-SI

14,15-EET-SI is a sulfonimide (SI) analog metabolized from 14,15-EET, which is also an effective mitogen. 14,15-EET-SI can stimulate the incorporation of [3H] thymidine, activate pp60c-src and initiate the tyrosine kinase cascade, mediating their mitotic effects. Additionally, 14,15-EET-SI can increase cell proliferation as well as the expression of c-fos and egr-1 mRNA[1].

Product Specifications

CAS Number

[218461-97-3]

UNSPSC

12352005

Hazard Statement

H225-H302-H319-H336

Target

Drug Derivative; Mitosis

Type

Reference compound

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/14-15-eet-si.html

Solubility

10 mM in DMSO

Smiles

CS(NC(CCC/C=C\C/C=C\C/C=C\CC1C(O1)CCCCC)=O)(=O)=O

Molecular Formula

C21H35NO4S

Molecular Weight

397.57

Precautions

P210-P233-P240-P241-P242-P243-P261-P264-P270-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P330-P370+P378-P403+P233-P403+P235-P405-P501

References & Citations

[1]Chen JK, et al. Epoxyeicosatrienoic acids and their sulfonimide derivatives stimulate tyrosine phosphorylation and induce mitogenesis in renal epithelial cells. J Biol Chem. 1998 Oct 30;273 (44) :29254-61.