ES 936

ES 936 is a potent and specific NQO1 inhibitor. ES 936 inhibits the growth of MIA PaCa-2 and BxPC-3 cells, with IC50 values of 108 nM and 365 nM, respectively. ES936 significantly inhitbits the growth rate of MIA PaCa-2 xenograft tumors in mice. ES 936 can be used for the study of pancreatic cancer[1][2][3].

Product Specifications

CAS Number

[192820-78-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

NF-κB; Quinone Reductase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/es-936.html

Purity

98.66

Solubility

DMSO : 2 mg/mL (ultrasonic; warming)

Smiles

O=C(C(OC)=C1)C2=C(N(C)C(C)=C2COC3=CC=C([N+]([O-])=O)C=C3)C1=O

Molecular Formula

C18H16N2O6

Molecular Weight

356.33

Precautions

H302, H315, H319, H335

References & Citations

[1]Dehn DL, et al. Biochemical, cytotoxic, and genotoxic effects of ES936, a mechanism-based inhibitor of NAD (P) H:quinone oxidoreductase 1, in cellular systems. Mol Pharmacol. 2003 Sep;64 (3) :714-20. |[2]Dehn DL, et al. 5-Methoxy-1,2-dimethyl-3-[ (4-nitrophenoxy) methyl]indole-4,7-dione, a mechanism-based inhibitor of NAD (P) H:quinone oxidoreductase 1, exhibits activity against human pancreatic cancer in vitro and in vivo. |[3]Zhou H, et al. NAD (P) H:quinone oxidoreductase 1-compromised human bone marrow endothelial cells exhibit decreased adhesion molecule expression and CD34+ hematopoietic cell adhesion. J Pharmacol Exp Ther. 2010 Jul;334 (1) :260-8.