YGsy2p-IN-1
YGsy2p-IN-1 is a potent inhibitor for yeast glycogen synthase 2 (yGsy2p) . yGsy2p-IN-1 is a competitive human glycogen synthase 1 (hGYS1) inhibitor with an IC50 of 2.75 μM and a Ki of 1.31 μM for wild-type hGYS1. yGsy2p-IN-H23 a pyrazole inhibitor, is used for glycogen storage diseases (GSDs) [1].
Product Specifications
CAS Number
[2415003-97-1]
UNSPSC
12352005
Target
Others
Type
Reference compound
Related Pathways
Others
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/ygsy2p-in-h23.html
Concentration
10mM
Purity
98.57
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
OC1=CC=C(C2=NNC(C(F)(F)F)=C2C3=CC=C(O)C=C3)C(O)=C1O
Molecular Formula
C16H11F3N2O4
Molecular Weight
352.26
References & Citations
[1]Buyun Tang, et al. Discovery and Development of Small-Molecule Inhibitors of Glycogen Synthase. J Med Chem. 2020 Apr 9;63 (7) :3538-3551.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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