OTS186935
OTS186935 is a potent protein methyltransferase SUV39H2 inhibitor with an IC50 of 6.49 nM. OTS186935 shows significant inhibition of tumor growth in mouse xenograft models without any detectable toxicity. OTS193320 regulates the production of γ-H2AX in cancer cells[1].
Product Specifications
CAS Number
2093400-18-9
UNSPSC
12352005
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ots186935.html
Purity
99.69
Solubility
10 mM in DMSO
Smiles
COC1=C(Cl)C=C(C2=CN3C=CC(N4C[C@@H](NCC5=CC=NC=C5)CC4)=CC3=N2)C(OC)=C1
Molecular Formula
C25H26ClN5O2
Molecular Weight
463.96
References & Citations
[1]Vougiouklakis T, et al. Development of novel SUV39H2 inhibitors that exhibit growth suppressive effects in mouse xenograft models and regulate the phosphorylation of H2AX. Oncotarget. 2018 Aug 7;9 (61) :31820-31831.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SUV39H2/KMT1B
Citation 01
Acta Neuropathol. 2022 Nov;144 (5) :1027-1048.|Cell Death Discov. 2025 Aug 23;11 (1) :402.|Research Square Preprint. 2024 Feb 7.|Mol Cell. 2024 Nov 25:S1097-2765 (24) 00914-6.
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