OTS186935

OTS186935 is a potent protein methyltransferase SUV39H2 inhibitor with an IC50 of 6.49 nM. OTS186935 shows significant inhibition of tumor growth in mouse xenograft models without any detectable toxicity. OTS193320 regulates the production of γ-H2AX in cancer cells[1].

Product Specifications

CAS Number

[2093400-18-9]

UNSPSC

12352005

Target

Histone Methyltransferase

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ots186935.html

Purity

99.69

Solubility

10 mM in DMSO

Smiles

COC1=C(Cl)C=C(C2=CN3C=CC(N4C[C@@H](NCC5=CC=NC=C5)CC4)=CC3=N2)C(OC)=C1

Molecular Formula

C25H26ClN5O2

Molecular Weight

463.96

References & Citations

[1]Vougiouklakis T, et al. Development of novel SUV39H2 inhibitors that exhibit growth suppressive effects in mouse xenograft models and regulate the phosphorylation of H2AX. Oncotarget. 2018 Aug 7;9 (61) :31820-31831.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

SUV39H2/KMT1B

Citation 01

Acta Neuropathol. 2022 Nov;144 (5) :1027-1048.|Cell Death Discov. 2025 Aug 23;11 (1) :402.|Research Square Preprint. 2024 Feb 7.|Mol Cell. 2024 Nov 25:S1097-2765 (24) 00914-6.