Kamebakaurin
Product Specifications
CAS Number
73981-34-7
Target
NF-κB, Caspase, Apoptosis, HIF/HIF Prolyl-Hydroxylase
Related Pathways
NF-κB, Proteases/Proteasome, Metabolism, Apoptosis, Chromatin/Epigenetic
Purity
0.9805
Bioactivity
1. Kamebakaurin (Kamebakaurine) has the ability to protect the liver from APAP-induced hepatotoxicity, presumably by both inhibiting the inflammatory response and oxidative stress. 2. Kamebakaurin inhibits the expression of hypoxia-inducible factor-1α and its target genes to confer antitumor activity. 3. Kamebakaurin has anti-cancer and anti-inflammatory activities through direct inhibition of DNA-binding activity of nuclear factor-kappa B (NF-κB) p50.4. Kamebakaurin has anti-neuroinflammatory activity via inhibition of c-Jun NH -terminal kinase and p38 mitogen-activated protein kinase pathway in activated microglial cells.
Smiles
[H][C@@]1(O)[C@H]2CC[C@]3([H])[C@]1([C@H](O)C[C@]1([H])C(C)CC[C@H](O)[C@@]31CO)C(=O)C2=C
Molecular Formula
C20H30O5
Molecular Weight
350.45
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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