AV-412 free base
Product Specifications
CAS Number
451492-95-8
Target
EGFR
Related Pathways
Angiogenesis, Tyrosine Kinase/Adaptors, JAK/STAT signaling
Bioactivity
AV-412 free base is an EGFR inhibitor (IC50s: 0.75, 0.79, 0.5, 2.3, 19 nM for EGFR, EGFR (T790M), EGFR (L858R), EGFR (L858R/T790M) and ErbB2) .
Smiles
CN1CCN(CC1)C(C)(C)C#Cc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)C=C
Molecular Formula
C27H28ClFN6O
Molecular Weight
507
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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