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Falnidamol

Product Specifications

CAS Number

196612-93-8

Target

EGFR

Related Pathways

Tyrosine Kinase/Adaptors, JAK/STAT signaling, Angiogenesis

Purity

0.98816

Bioactivity

Falnidamol (BIBX 1382) is an orally active, selective EGFR tyrosine kinase inhibitor with an IC50 of 3 nM. It displays >1000-fold lower potency against ErbB2 (IC50=3.4 μM) and other related tyrosine kinases (IC50>10 μM) . Falnidamol is a pyrimido-pyrimidine compound and exhibits anti-cancer activity.

Smiles

CN1CCC(CC1)Nc1ncc2ncnc(Nc3ccc(F)c(Cl)c3)c2n1

Molecular Formula

C18H19ClFN7

Molecular Weight

387.84

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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