LDC1267
LDC1267 is a highly selective TAM (Tyro3, Axl and Mer) kinase inhibitor with IC50s of [1].
Product Specifications
CAS Number
[1361030-48-9]
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
TAM Receptor
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/LDC1267.html
Purity
99.64
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
FC1=CC(NC(C2=NN(C3=CC=C(F)C=C3C)C=C2OCC)=O)=CC=C1OC4=CC=NC5=CC(OC)=C(OC)C=C54
Molecular Formula
C30H26F2N4O5
Molecular Weight
560.55
Precautions
H315, H319, H320
References & Citations
[1]Paolino M, et al. The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells. Nature. 2014 Mar 27;507 (7493) :508-12.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Axl; Mer; Tyro3
Available Sizes
Curated Selection
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