Tirabrutinib
Product Specifications
CAS Number
1351636-18-4
Target
BTK, Apoptosis
Related Pathways
Tyrosine Kinase/Adaptors, Apoptosis, Angiogenesis
Purity
0.9975
Bioactivity
Tirabrutinib (GS-4059) (ONO-4059) is an orally active Bruton's Tyrosine Kinase (Btk) inhibitor (can cross the blood-brain barrier (BBB) ), with an IC50 of 6.8 nM. Tirabrutinib irreversibly and covalently binds to Btk and inhibits aberrant B cell receptor signaling. Tirabrutinib can be used in studies of autoimmune diseases and hematological malignancies.
Smiles
CC#CC(=O)N1CC[C@H](C1)n1c2ncnc(N)c2n(-c2ccc(Oc3ccccc3)cc2)c1=O
Molecular Formula
C25H22N6O3
Molecular Weight
454.48
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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