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Tirabrutinib

Product Specifications

CAS Number

1351636-18-4

Target

BTK, Apoptosis

Related Pathways

Tyrosine Kinase/Adaptors, Apoptosis, Angiogenesis

Purity

0.9975

Bioactivity

Tirabrutinib (GS-4059) (ONO-4059) is an orally active Bruton's Tyrosine Kinase (Btk) inhibitor (can cross the blood-brain barrier (BBB) ), with an IC50 of 6.8 nM. Tirabrutinib irreversibly and covalently binds to Btk and inhibits aberrant B cell receptor signaling. Tirabrutinib can be used in studies of autoimmune diseases and hematological malignancies.

Smiles

CC#CC(=O)N1CC[C@H](C1)n1c2ncnc(N)c2n(-c2ccc(Oc3ccccc3)cc2)c1=O

Molecular Formula

C25H22N6O3

Molecular Weight

454.48

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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