Ailanthone
Product Specifications
CAS Number
981-15-7
Target
Androgen Receptor
Related Pathways
Endocrinology/Hormones
Purity
0.9996
Bioactivity
Ailanthone (AIL) is a natural compound derived from the tree Ailanthus altissima and has anti-hepatocellular carcinoma (HCC) properties. It can induce G0/G1 phase cell cycle arrest by downregulating the expression of cyclins and CDKs, while upregulating the expression of p21 and p27. Additionally, Ailanthone is a potent androgen receptor (AR) inhibitor, capable of inhibiting both the full-length androgen receptor (IC50: 69 nM) and constitutively active splice variants (IC50: 309 nM) .
Smiles
[H][C@]12[C@@]3(O)OC[C@@]11[C@@]([H])(C[C@@]4([H])C(C)=CC(=O)[C@@H](O)[C@]24C)OC(=O)C[C@@]1([H])C(=C)[C@H]3O
Molecular Formula
C20H24O7
Molecular Weight
376.4
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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