VH-298
Product Specifications
CAS Number
2097381-85-4
Target
Ligand for E3 Ligase, HIF/HIF Prolyl-Hydroxylase, HIF
Related Pathways
Angiogenesis, PROTAC, Metabolism, Chromatin/Epigenetic
Purity
>99.99%
Bioactivity
VH-298 is a potent inhibitor of VHL that stabilizes HIF-α and elicits a hypoxic response via a different mechanism, that is the blockade of the VHL:HIF-α protein-protein interaction downstream of HIF-α hydroxylation by PHD enzymes.
Smiles
Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(CC2)C#N)C(C)(C)C)cc1
Molecular Formula
C27H33N5O4S
Molecular Weight
523.65
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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