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VH-298

Product Specifications

CAS Number

2097381-85-4

Target

Ligand for E3 Ligase, HIF/HIF Prolyl-Hydroxylase, HIF

Related Pathways

Angiogenesis, PROTAC, Metabolism, Chromatin/Epigenetic

Purity

>99.99%

Bioactivity

VH-298 is a potent inhibitor of VHL that stabilizes HIF-α and elicits a hypoxic response via a different mechanism, that is the blockade of the VHL:HIF-α protein-protein interaction downstream of HIF-α hydroxylation by PHD enzymes.

Smiles

Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(CC2)C#N)C(C)(C)C)cc1

Molecular Formula

C27H33N5O4S

Molecular Weight

523.65

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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