LY 3000328
Product Specifications
CAS Number
1373215-15-6
Target
Cysteine Protease
Related Pathways
Proteases/Proteasome
Purity
0.9954
Bioactivity
LY 3000328 (Cathepsin S inhibitor) is a selective inhibitor of cathepsin S with IC50 values of 7.7 and 1.67 nM for human and mouse cathepsin S, respectively. LY 3000328 (Cathepsin S inhibitor) may slow or prevent abdominal aortic aneurysm (AAA) expansion and/or reduce the risk of AAA rupture by inhibiting cathepsin S-mediated degradation of extracellular matrix proteins, elastin and collagen.
Smiles
CNC(=O)O[C@H]1COc2ccc(cc2[C@@H]1NC(=O)c1ccc(F)cc1)N1CCN(CC1)C1COC1
Molecular Formula
C25H29FN4O5
Molecular Weight
484.52
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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