PMX 53 acetate (219639-75-5 free base)
Product Specifications
CAS Number
852629-88-0
Target
Endogenous Metabolite|||Complement System
Related Pathways
Metabolism|||Immunology/Inflammation
Purity
0.9991
Bioactivity
PMX-53 is a potent and orally active CD88 (C5aR) antagonist (IC50: 20 nM) and inhibits C5a-induced neutrophil myeloperoxidase release and chemotaxis with IC50 values of 22 nM and 75 nM, respectively. PMX-53 is also an agonist of Mas-related gene 2 (MrgX2) .
Smiles
N=C(N)NCCC[C@@H]1NC([C@H](CC2=CNC3=C2C=CC=C3)NC([C@@H](CC4CCCCC4)NC([C@H]5N(C([C@H](CCCNC1=O)NC([C@H](CC6=CC=CC=C6)NC(C)=O)=O)=O)CCC5)=O)=O)=O.CC(O)=O
Molecular Formula
C49H69N11O9
Molecular Weight
956.16
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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