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Cannflavin B

Cannflavin B is a flavonoid compound that can be isolated from Cannabis sativa L. Cannflavin B is inhibitors of PGE2 release (IC50: 0.7 μM), mPGES-1 (IC50: 3.7 μM), and 5-lipoxygenase. Cannflavin B has multiple activities such as anti-inflammatory, antioxidant, anti-glycation, anti-ferroptosis, anti-tumor, and anti-Leishmania (IC50: 14 μM) . Cannflavin B can also inhibit the TrkB-BDNF signaling pathway[1][2][3][4].

Product Specifications

CAS Number

[76735-58-5]

Product Name Alternative

Canniflavone

UNSPSC

12352005

Target

Akt; Ferroptosis; Lipoxygenase; mTOR; p38 MAPK; Parasite; PGE synthase; Trk Receptor

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Neuronal Signaling; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cannflavin-b.html

Purity

98.36

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1C=C(C2=CC(OC)=C(O)C=C2)OC3=CC(O)=C(C/C=C(C)\C)C(O)=C13

Molecular Formula

C21H20O6

Molecular Weight

368.38

References & Citations

Cannabis sativa[1]

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture)

Scientific Category

Natural Products

Clinical Information

No Development Reported

Isoform

5-LOX; TrkB

Available Sizes

Curated Selection

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